Pesticides in the Blood Samples of Spray-workers at Agriculture Environment: The Toxicological Evaluation

Pesticides are major contaminating chemicals in agriculture environment and a hazard to exposed population. These compounds are absorbed by inhalation, ingestion, and dermal contact. Their bioavailability in the individuals can lead to a variety of metabolic and systemic dysfunctions, and even outright disease states. Therefore, the tremendous usage of pesticides has promoted toxicological studies in spraying community. This study comprising pesticide spray-workers (n=140) and controls (n=110) indicated highly significant effects by analytical means on serum cholinesterase level (p<0.001) through ANOVA. Duncan Multiple Range Test ranking for monocrotophos and carbaryl were similar though different than endosulfan and cypermethrin, which conceptualized the effects on cholinesterase level. The GC-MS detection of residue concentrations in blood serum samples of spray-workers; calculated for endosulfan, monocrotophos, carbaryl and cypermethrin were 0.009, 0.005, 0.05 and 0.08 mg/kg body weight respectively. It was further seen in light of reported NOAEL that indicated the effect and extent of exposure among the study population.